Search results for " pharmacoepidemiology"

showing 5 items of 5 documents

Polypharmacy in people with dementia: Associations with adverse health outcomes

2018

Polypharmacy has been linked to higher risks of hospitalisation and death in community samples. It is commonly present in people with dementia but these risks have rarely been studied in this population. We aimed to investigate associations between polypharmacy and emergency department attendance, any and unplanned hospitalisation, and mortality in patients with dementia. Using a large mental health care database in South London, linked to hospitalisation and mortality data, we assembled a retrospective cohort of patients diagnosed with dementia. We ascertained number of medications prescribed at the time of dementia diagnosis and conducted multivariate Cox regression analyses. Of 4668 pati…

MaleAgingmedicine.medical_specialtyDatabases FactualPopulationBiochemistry03 medical and health sciences0302 clinical medicineEndocrinologyRisk FactorsLondonDementia; Emergency department; Hospitalisation; Mortality; Pharmacoepidemiology; PolypharmacyGeneticsmedicineHospitalisationDementiaHumans030212 general & internal medicineMortalityeducationMolecular BiologyAgedRetrospective StudiesPolypharmacyAged 80 and overeducation.field_of_studyProportional hazards modelbusiness.industryEmergency departmentPharmacoepidemiologyHazard ratioAttendanceRetrospective cohort studyCell BiologyEmergency departmentmedicine.diseaseSurvival AnalysisHospitalizationEmergency medicineMultivariate AnalysisPolypharmacyFemaleDementiabusinessEmergency Service Hospital030217 neurology & neurosurgery
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Prescription of Antithrombotic Therapy in Older Patients Hospitalized for Transient Ischemic Attack and Ischemic Stroke: The GIFA Study

2004

Background and Purpose— Antithrombotic therapy has been demonstrated as an effective tool for secondary ischemic stroke prevention. Nevertheless, scant data are available on actual prescription of this therapy in clinical practice. Methods— A total of 17 337 patients admitted to geriatric and internal medicine wards participating in the study in the 1993 to 1998 survey period were analyzed. Patients with coded diagnoses of ischemic stroke and transient ischemic attack (TIA) were selected. Data recorded included demographic and clinical characteristics and medication prescription during hospital stay and at discharge. Logistic regression analyses were used to identify conditions associated …

MaleAgingmedicine.medical_specialtypharmacoepidemiologyEpidemiologymedicine.drug_classIschemiaMedication prescriptionNOBrain Ischemiastroke; prevention; aging; antithrombotic therapy; pharmacoepidemiologypreventionFibrinolytic AgentsEpidemiologyAntithromboticmedicineHumansMedical prescriptionStrokeAgedDemographyAntithrombotic therapyAdvanced and Specialized Nursingbusiness.industryAnticoagulantAnticoagulantsOdds ratiomedicine.diseaseHospitalizationStrokeIschemic Attack TransientAcute DiseaseEmergency medicinePhysical therapyFemaleNeurology (clinical)Cardiology and Cardiovascular MedicinebusinessPlatelet Aggregation InhibitorsStroke
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Prevalence of potentially inappropriate medications and risk of adverse clinical outcome in a cohort of hospitalized elderly patients: results from t…

2014

SummaryWhat is known and objective Inappropriate prescribing is highly prevalent for older people and has become a global healthcare concern because of its association with negative health outcomes including ADEs, hospitalization and resource utilization. Beers' criteria are widely utilized for evaluating the appropriateness of medications, and an up-to-date version has recently been published. To assess the prevalence of patients exposed to PIMs at hospital discharge according to the 2003 and 2012 versions of Beers' criteria and to evaluate the risk of adverse clinical events, re-hospitalization and all-cause mortality at 3-month follow-up. Methods This cross-sectional study was held in 66…

Malemedicine.medical_specialtyMultivariate analysispharmacoepidemiologyHealth Services for the AgedBeers CriteriaPatient Discharge SummariesInappropriate PrescribingelderlyCohort StudiesBeers' criteriaBeers' criteria; elderly; pharmacoepidemiology; Aged; Aged 80 and over; Cohort Studies; Cross-Sectional Studies; Female; Humans; Inappropriate Prescribing; Italy; Male; Patient Discharge Summaries; Polypharmacy; Prevalence; Health Services for the Aged; Pharmacology (medical); Pharmacology; Medicine (all)Health careBeer's criteria80 and overPrevalencemedicineHumansDementiaPharmacology (medical)Medical prescriptionPsychiatryAdverse effectAgedAged 80 and overPharmacologybusiness.industryMedicine (all)Pharmacoepidemiologymedicine.diseaseCross-Sectional StudiesItalyCohortEmergency medicinePolypharmacyFemalebusinessBeer's criteria; elderly; pharmacoepidemiology
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Pattern of in-hospital changes in drug use in the older people from 2010 to 2016

2017

Purpose: To assess the pattern of in-hospital changes in drug use in older patients from 2010 to 2016. Methods: People aged 65 years or more acutely hospitalized in those internal medicine and geriatric wards that did continuously participate to the REgistro POliterapie Società Italiana di Medicina Interna register from 2010 to 2016 were selected. Drugs use were categorized as 0 to 1 drug (very low drug use), 2 to 4 drugs (low drug use), 5 to 9 drugs (polypharmacy), and 10 or more drugs (excessive polypharmacy). To assess whether or not prevalence of patients in relation to drug use distribution changed overtime, adjusted prevalence ratios (PRs) was estimated with log-binomial regression mo…

RegistrieMalepharmacoepidemiologyEpidemiologyDischarged alive030204 cardiovascular system & hematologyinternal medicine and geriatric warddrug use; excessive polypharmacy; internal medicine and geriatric wards; older people; pharmacoepidemiology; polypharmacyexcessive polypharmacyolder people0302 clinical medicineDrug PrescriptionRisk Factors80 and overPharmacology (medical)030212 general & internal medicineRegistriesAt-Risk Populationmedia_commonAged 80 and overOvertimedrug use excessive polypharmacy internal medicine and geriatric wards older people pharmacoepidemiology polypharmacyinternal medicine and geriatric wardsPharmacoepidemiologyHospitalizationItalyFemaleMedical emergencyHumanDrugmedicine.medical_specialtymedia_common.quotation_subjectSocio-culturaleDrug Prescriptions03 medical and health sciencesHospital dischargemedicineInternal MedicineHumanspolypharmacyAgeddrug usePolypharmacyInpatientsbusiness.industryRisk Factormedicine.diseasedrug use; excessive polypharmacy; internal medicine and geriatric wards; older people; pharmacoepidemiology; polypharmacy; Aged; Aged 80 and over; Drug Prescriptions; Female; Hospitalization; Humans; Internal Medicine; Italy; Male; Polypharmacy; Registries; Risk Factors; InpatientsEmergency medicinePolypharmacyOlder peoplebusiness
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7. INAPPROPRIATE PRESCRIPTION OF ALLOPURINOL AND FEBUXOSTAT AND RISK OF ADVERSE EVENTS IN THE ELDERLY: RESULTS FROM THE REPOSI REGISTRY

2014

Purpose To investigate the prevalence of xanthine oxidase (XO) inhibitors prescription at admission and discharge in elderly hospital in-patients, to analyze the appropriateness of their use in relation to evidence-based indications, to evaluate the predictors of inappropriate prescription at discharge and the association with adverse events 3 months after hospital discharge. Methods This cross-sectional study, based upon a prospective registry, was held in 95 Italian internal medicine and geriatric hospital wards. The sample included 4035 patients aged 65 years or older at admission and 3502 at discharge. The prescription of XO inhibitors was considered appropriate in patients with diagnos…

Settore MED/09 - Medicina InternaAged . Pharmacoepidemiology . Allopurinol
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